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BTW. Of course this is offensive. I needed to go off the reservation today. Sorry! Remember you signed up for this.
Ozempic and other weight loss drugs could help treat alcohol and drug addiction, study says
A new study found that GLP-1 drugs like Ozempic and Mounjaro helped people with substance abuse disorders
By Bruce Gil, Quartz
PublishedYesterday
The case that Ozempic and other GLP-1 medications could help people with substance use disorders is getting stronger.
Blockbuster diabetes and weight loss drugs, known as GLP-1 treatments, could help people struggling with alcohol and opioid addiction, according to a new study published Thursday in the scientific journal Addiction.
In a retrospective study, researchers found that patients with opioid use disorder who had a GLP-1 prescription had a 40% lower rate of opioid overdoses compared with those without a prescription.
Additionally, people with alcohol use disorder with a GLP-1 prescription had 50% fewer instances of alcohol intoxication compared with those without a prescription.
Researchers from the Loyola University Chicago made the findings by analyzing the medical records of over 500,000 patients with substance use disorders.
GLP-1s are a class of diabetes and obesity medications that mimic a hormone that interacts with a region of the brain – the mesolimbic system – to reduce appetite and trigger satisfaction after eating. Demand for these medications has turned Ozempic maker Novo Nordisk and Eli Lilly, the producer of Mounjaro and Zepbound (both GLP-1 drugs for diabetes and weight loss), into the largest pharma companies in the world.
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Additionally, the mesolimbic system overlaps with the brain processes that influence addictive behaviors. This overlap suggests that these medications may “modulate the reward-response pathways associated with substance use,” the study authors wrote.
The study follows other anecdotal evidence from patients and healthcare providers that suggests GLP-1 drugs can help users curb addictions.
A Morgan Stanley survey from earlier this year found that people using GLP-1 drugs — among them Ozempic, Wegovy, Mounjaro, and Zepbound — reduced their consumption of tobacco.
The investment bank surveyed approximately 300 GLP-1 users about their consumption habits while taking the medication.
While 40% of survey respondents said they smoked cigarettes at least weekly before starting a GLP-1 treatment, that number fell to 24% after they started the treatment. Meanwhile, weekly e-cigarette usage dropped from 30% of respondents to 16% after they started taking a GLP-1.
The analysts noted they were “cautious about drawing conclusions” from their survey about the impact of GLP-1 drugs on addictive behaviors. While research hasn’t yet proven a causal link, clinical trials are currently underway to better understand the effects of GLP-1s on alcohol and tobacco consumption.
One small trial found that people with alcohol use disorder drank less after taking semaglutide — the active ingredient in Novo Nordisk’s Ozempic — compared with people who took a placebo.
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